DL-Dithiothreitol CAS 3483-12-3 DTT

Dithiothreitol is a commonly used reducing agent, also known as dithiothreitol (DTT), which has strong reducibility. Its reducibility is largely due to the conformational stability of its oxidized hexagonal ring (containing disulfide bonds). The reducing power is affected by pH value and can only exert a reducing effect when the pH value is greater than 7. This is because only protonated thiol salt anions (- S -) have reactivity, while thiols (- SH) do not; The pKa of thiol groups is generally around 8.3.

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Model:
3483-12-3
Brand:
bosschemical
Code:
3483-12-3

Product Description

DL-Dithiothreitol Basic information
Product Name:	DL-Dithiothreitol
CAS:	578517
MF:	C4H10O2S2
MW:	154.25
EINECS:	222-468-7
Mol File:	3483-12-3.mol
DL-Dithiothreitol Chemical Properties
Melting point	41-44 °C(lit.)
Boiling point	125 °C
alpha	-0.2～+0.2°(20℃/D)(c=5,H2O)
bulk density	300kg/m3
density	1.04 g/mL at 20 °C
vapor density	5.3 (vs air)
vapor pressure	0.019-0.29Pa at 20-50℃
refractive index	1.5200 (estimate)
Fp	>230 °F
storage temp.	-20°C (or 4°C short term).
solubility	H2O: 50 mg/mL, clear, colorless
form	Powder
pka	pK1:8.9 (25°C)
color	White
PH	4.0-6.0 (20-25℃, 0.1m in H2O)
Odor	Unpleasant Odor
PH Range	4 - 6 at 15,4 g/l at 25 °C
biological source	synthetic
Water Solubility	freely soluble
Sensitive	Air Sensitive
λmax	λ: 260 nm Amax: 0.400
λmax	λ: 280 nm Amax: 0.100
Merck	143,376
BRN	1719757
Stability:	Stability Stable, but heat sensitive. Incompatible with strong oxidizing agents. Keep frozen at -20 to -10 C.
InChIKey	VHJLVAABSRFDPM-UHFFFAOYSA-N
LogP	0.07 at 25℃ and pH5
CAS DataBase Reference	3483-12-3(CAS DataBase Reference)
NIST Chemistry Reference	2,3-Butanediol, 1,4-dimercapto-, (r,r)-(3483-12-3)
EPA Substance Registry System	1,4-Dithiothreitol (3483-12-3)
Absorption	cut-off at 330nm

DL-Dithiothreitol CAS 3483-12-3 DTT C4H10O2S2 Protein reducing agent Enzyme activity maintainer

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Chemical detection methods

Spectroscopic Analysis Methods

Ultraviolet-Vis Spectrophotometry (UV-Vis)
Infrared Spectroscopy (IR/FTIR)
Atomic Absorption Spectroscopy (AAS)
X-ray Fluorescence Spectroscopy (XRF)
Nuclear Magnetic Resonance Spectroscopy (NMR)

Chromatographic Analysis

Gas Chromatography (GC)
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Mass Spectrometry Analysis

GC-MS / LC-MS/MS: Qualitative and Quantitative Analysis
ICP-MS: Trace Metal Elements (ppb Level)
TOF-MS: Precise Molecular Weight Determination

Electrochemical analysis methods

Polypotentiometric methods
Conductivity methods
Polarographic methods / Voltammetric methods
Coulometric analysis

Thermal Analysis Methods

Thermogravimetric Analysis (TGA)
Differential Scanning Calorimetry (DSC)
Differential Thermal Analysis (DTA)

Classical wet chemical analysis

Titration analysis
Gravity analysis