PEG 400/2000/4000

PEG Introduction

A mixture of ethylene oxide and water for ring-opening polymerization. The molecular formula is expressed as HO(CH2CH2O)nH, where n represents the average number of oxyvinyls.

PEG is colorless viscous liquid or white solid. Low toxicity! Soluble in water and many organic solvents, readily soluble in aromatic hydrocarbons, slightly soluble in aliphatic hydrocarbons. Polyethylene glycol is very stable, but it can interact with oxygen in the air at 120℃ or higher.

The properties vary according to the relative molecular mass, from colorless and odorless viscous liquid to waxy solid. The molecular weight of 200-600 is liquid at room temperature, and the molecular weight of 600 or more gradually becomes semi-solid. From colorless and odorless sticky liquid to waxy solid. As the molecular weight increases, its moisture absorption capacity decreases accordingly.

The main role of PEG

Product Application In addition to being used as an intermediate in the synthesis of surfactants, plasticizers and lubricants, PEG can also be used in many industrial fields.

Types of PEG

PEG-200: humectant, viscosity modifier, etc.;

PEG-400, PEG-600, PEG-800: the matrix of medicine and cosmetics, in which PEG-600 can be added to the electrolyte in metal processing to enhance the gloss of the metal surface;

PEG-1000, PEG-1500: used as a base or lubricant in the fields of medicine, textile and cosmetics, softener ;

PEG-8000: Matrix in pharmaceutical and cosmetic fields, lubricants and coolants in rubber and metal processing, dispersants and emulsifiers in pesticide and pigment industries, antistatic agents and lubricants in textile industry, etc.

PEG types.

Polyethylene Glycol 6000 (PEG-6000),

Polyethylene Glycol 4000 (PEG-4000),

Polyethylene Glycol 600 (PEG-600),

Polyethylene Glycol 400 (PEG-400),

Polyethylene Glycol 200 (PEG-200)

Polyethylene Glycol 200 (PEG-200)

Properties and advantages of polyethylene glycol 200: non-toxic, non-irritating, good water solubility, good compatibility with many components.

Appearance (25℃): colorless and transparent liquid

Color(Pt-Co):≤20

Hydroxyl value (mgKOH/g): 510～623

Molecular weight: 180～220

Water content (%): ≤1.0

pH value (1% aqueous solution): 5.0～7.0

This product can be used as pharmaceutical. It can be used as solvent, co-solvent, o/w type emulsifier and stabilizer. It can be used as medium for organic synthesis and heat carrier with high requirements, as moisturizer, inorganic salt solubilizer and viscosity adjuster in daily chemical industry; as softener and antistatic agent in textile industry; as wetting agent in paper and pesticide industry. It can be used as the raw material of ester surfactant

【Package】

Packed in 1100kg square tank, 200kg plastic drum, 50kg plastic drum.

【Storage】

This product is non-toxic, non-flammable, stored and transported as general chemicals. Store in dry and ventilated place. Shelf life two years.

Polyethylene glycol 400 (PEG-400)

Appearance (25℃): colorless and transparent liquid

Color(Pt-Co): ≤20

Hydroxyl value (mgKOH/g): 255～312

Molecular weight：360～440

Freezing point (℃): 4～10

Water content (%): ≤1.0

pH value (1% aqueous solution): 5.0～7.0

Property:This product is a colorless or almost colorless viscous liquid; slightly special odor. Solubility:This product is soluble in water or ethanol, insoluble in ether. Movement viscosity at 40℃ (capillary inner diameter is 0.8mm), should be 37~45mm<2>/s. Need to be sealed and stored.

Role in bioengineering:Used as an intermediate inducer of plant cell fusion. This product can be used in pharmaceuticals. It can be used as solvent, co-solvent, o/w type emulsifier and stabilizer. It can be used as a base for pharmaceuticals and cosmetics, lubricant and wetting agent for rubber industry and textile industry. It is used to make cement suspension, emulsion, injection, etc. It is also used as water-soluble ointment base and suppository base. It can be used as the raw material of ester type surfactant.

【Package】

Packed in 1100kg square tank, 200kg iron drum, 50kg plastic drum.

【Storage】

This product is non-toxic, non-flammable, stored and transported as general chemicals. Store in dry and ventilated place. Shelf life is two years.

Polyethylene Glycol 600 (PEG-600)

Polyethylene glycol 600 is a colorless or almost colorless viscous liquid, or a translucent waxy soft substance with a slight characteristic odor. It is easily soluble in water or ethanol, but insoluble in ether. It is similar to polyethylene glycol 400 (PEG-400).

In biochemical experiments, it has various uses, including.

1) After activation, it can bind peptides or proteins and be used to precipitate proteins.

2) As a fusion agent to enhance the formation of macrophage hybridomas.

3) Isolation and purification of biological macromolecules.

4) Inducing cell hybridization, etc.

Polyethylene Glycol 4000 (PEG-4000)

Appearance (25℃): milky white solids

Color（Pt-Co）：≤50

Hydroxyl value (mgKOH/g): 26～32

Molecular weight: 3600～4400

Freezing point (℃): 53～54

Water content (%): ≤1.0

pH value (1% aqueous solution): 5.0～7.0

This product can be used in pharmaceuticals. It is used as a substrate in the production of pharmaceutical and cosmetic industries, playing the role of regulating viscosity and melting point; used as a finishing agent in the paper industry to increase the gloss and smoothness of paper; used as an additive in the rubber industry to increase the lubricity and plasticity of rubber products, reduce the power consumption during processing and prolong the service life of rubber products; used as a lubricant and coolant in the metal processing industry, and used as a dispersant and emulsifier in the production of pesticides and pigments It is used as dispersant and emulsifier in the production of pesticide and pigment industry; used as antistatic agent and lubricant in the textile industry.

【Package】

25kg kraft paper bag, 20kg woven bag.

【Storage】

This product is non-toxic, non-flammable, stored and transported as general chemicals. Store in dry and ventilated place.

Shelf life: 2 years

Polyethylene Glycol 6000 (PEG-6000)

On the one hand, PEG 4000 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (e.g. yeast) to take in DNA during transformation, as they can absorb water from the solution. PEG is used to concentrate solutions. PEG is a white, waxy, solid flake or granular powder; slightly odorous. The product is soluble in water or ethanol, but insoluble in ether.

The development trend of PEG

Polyethylene glycol (PEG) is the polymer with the lowest level of absorption by proteins and cells among the known polymers so far. It is non-toxic, harmless and non-irritating to the human body, and has good biocompatibility. It was originally used in ointments and suppositories. , drop pills, hard capsules, eye drops, injections and tablets and other pharmaceuticals have been used.

Since the 1990s, new PEG-modified drug R&D projects have emerged, and it has gradually become a new option in the development of new drug formulations. The application of PEGylation technology has expanded from the modification of macromolecular protein drugs to the modified drug delivery of small molecules, and to mRNA vaccines, spanning many fields such as peptides, proteins, enzymes, small molecules, and RNA.

Materials with a molecular weight of less than 20,000 g/mol are called PEG and have a wide range of downstream applications. They are commonly used in biomedical research such as drug delivery, tissue engineering, bioconjugation and surface functionalization. They are the world's most advanced pharmaceutical molecule modification and drug delivery technology . When coupled to the surface of a drug molecule, it can change the solubility of the drug molecule, form a spatial barrier to reduce enzymatic hydrolysis, and has outstanding advantages such as attenuating toxicity, reducing immunogenicity, prolonging half-life, changing tissue distribution and increasing the concentration of the target site. Long-term mainstream solutions.

PEG is non-toxic and has been approved by FDA and other institutions. With the change of molecular weight, the properties of the products are also quite different. At present, polyethylene glycol can be divided into PEG200-PEG8000, of which the molecular weight of 200-600 is at room temperature. The product form is liquid, and as the molecular weight increases, the product form tends to be semi-solid. According to the difference of purity, it can be divided into several series such as pharmaceutical grade, cosmetic grade, food grade and industrial grade, which are used in pharmaceutical, food and cosmetic preparations.