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Glycyrrhizic Acid 1405-86-3

This product has a distinctive sweet taste, with a sweetness approximately 250 times that of table sugar. Sodium glycyrrhizate, extracted from licorice, retains its sweetness even when diluted 4,000 times in water. However, when used directly as a food sweetener, it is unsuitable for certain foods. Generally, it can be used in combination with natural sugars such as sucrose, glucose, and molasses, or appropriately blended with saccharin, glycine, and propylene glycol to achieve a more palatable sweetness. In 1978, Japan produced 240 tons of glycyrrhizic acid, with the raw material licorice imported from China and Russia. In the peak year, 12,000 tons of licorice were imported. Of the total sales in 1978, 26% was used in pharmaceuticals and cosmetics, 70% in food products, and 4% in cigarettes and other applications.
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  • 1405-86-3

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  • 1405-86-3

Glycyrrhizic acid Basic information

Description References

Product Name:

Glycyrrhizic acid

CAS:

1405-86-3

MF:

C42H62O16

MW:

822.94

EINECS:

215-785-7

Mol File:

1405-86-3.mol

Glycyrrhizic acid Chemical Properties

Melting point

220°C (rough estimate)

alpha

D17 +46.2° (c = 1.5 in alc)

Boiling point

681.01°C (rough estimate)

density

1.1442 (rough estimate)

refractive index

61 ° (C=1.5, EtOH)

storage temp.

under inert gas (nitrogen or Argon) at 2-8°C

solubility

DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly)

form

Solid

pka

2.76±0.70(Predicted)

color

White to Light Yellow

Odor

at 100.00 %. mild spicy

Odor Type

spicy

Merck

144,505

Stability:

Hygroscopic

Major Application

pharmaceutical (small molecule)

Cosmetics Ingredients Functions

SKIN CONDITIONING

HUMECTANT

Cosmetic Ingredient Review (CIR)

Glycyrrhizic acid (1405-86-3)

InChIKey

BXFBITNYMHAJGT-KYXJNIQISA-N

LogP

4.64

CAS DataBase Reference

1405-86-3

EPA Substance Registry System

Glycyrrhizin (1405-86-3)

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Chemical detection methods

  • Spectroscopic Analysis Methods

    Ultraviolet-Vis Spectrophotometry (UV-Vis)
    Infrared Spectroscopy (IR/FTIR)
    Atomic Absorption Spectroscopy (AAS)
    X-ray Fluorescence Spectroscopy (XRF)
    Nuclear Magnetic Resonance Spectroscopy (NMR)

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    Gas Chromatography (GC)
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    Ion Chromatography (IC)
    Thin Layer Chromatography (TLC)

  • Mass Spectrometry Analysis

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    ICP-MS: Trace Metal Elements (ppb Level)
    TOF-MS: Precise Molecular Weight Determination

  • Electrochemical analysis methods
    Polypotentiometric methods
    Conductivity methods
    Polarographic methods / Voltammetric methods
    Coulometric analysis
  • Thermal Analysis Methods
    Thermogravimetric Analysis (TGA)
    Differential Scanning Calorimetry (DSC)
    Differential Thermal Analysis (DTA)
  • Classical wet chemical analysis
    Titration analysis
    Gravity analysis
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