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22457-89-2
bosschem
22457-89-2
| Benfotiamine Basic information | |
| Product Name: | Benfotiamine |
| Synonyms: | benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester |
| CAS: | 22457-89-2 |
| MF: | C19H23N4O6PS |
| MW: | 466.45 |
| EINECS: | 245-013-4 |
| Product Categories: | API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds;22457-89-2 |
| Mol File: | 22457-89-2.mol |
| Benfotiamine Chemical Properties | |
| Melting point | 165 C |
| Boiling point | 745.1±70.0 °C(Predicted) |
| density | 1.444±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Heated, Sonicated) |
| form | Solid |
| pka | 1.84±0.10(Predicted) |
| color | White to Off-White |
| Merck | 141,041 |
| InChIKey | BTNNPSLJPBRMLZ-GHRIWEEISA-N |
| SMILES | C(C1=CN=C(C)N=C1N)N(C=O)C(C)=C(CCOP(O)(O)=O)SC(C1C=CC=CC=1)=O |
| CAS DataBase Reference | 22457-89-2(CAS DataBase Reference) |
Items | Standards | Results |
Appearance | White to light yellow crystalline power | White crystalline power |
Identification | The IR absorption spectrum is accordant with that of Benfotiamine CRS | Complies |
The retention time of main peak is accordant with that of Benfotiamine CRS | Complies | |
Appearance of solution | Colorless to light yellow clear solution | Colorless and clear solution |
Chlorides | Note more than 0.053% | <0.053% |
Sulphate | Note more than 0.011% | <0.011% |
Heavy metal | Note more than 0.002% | <0.002% |
Loss on drying | Note more than 1.5% | 0.53% |
Benzoic acid | Not detectable | Not detected |
Thiamine | NMT 0. 1% | < 0. 1% |
Assay | ≥99.0% | 99.8% |
Arsenic | Notemore than 1 ppm | <0.04 ppm |
Cadmium | Not more than 1 ppm | <0.003 ppm |
Lead | Not more than 1 ppm | <0.04 ppm |
E coli: | Negative | Negative |
Salmonellas | Negative |
|
Conclusion | The above product conforms to JP Standard | |
| Benfotiamine Basic information | |
| Product Name: | Benfotiamine |
| Synonyms: | benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester |
| CAS: | 22457-89-2 |
| MF: | C19H23N4O6PS |
| MW: | 466.45 |
| EINECS: | 245-013-4 |
| Product Categories: | API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds;22457-89-2 |
| Mol File: | 22457-89-2.mol |
| Benfotiamine Chemical Properties | |
| Melting point | 165 C |
| Boiling point | 745.1±70.0 °C(Predicted) |
| density | 1.444±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Heated, Sonicated) |
| form | Solid |
| pka | 1.84±0.10(Predicted) |
| color | White to Off-White |
| Merck | 141,041 |
| InChIKey | BTNNPSLJPBRMLZ-GHRIWEEISA-N |
| SMILES | C(C1=CN=C(C)N=C1N)N(C=O)C(C)=C(CCOP(O)(O)=O)SC(C1C=CC=CC=1)=O |
| CAS DataBase Reference | 22457-89-2(CAS DataBase Reference) |
Items | Standards | Results |
Appearance | White to light yellow crystalline power | White crystalline power |
Identification | The IR absorption spectrum is accordant with that of Benfotiamine CRS | Complies |
The retention time of main peak is accordant with that of Benfotiamine CRS | Complies | |
Appearance of solution | Colorless to light yellow clear solution | Colorless and clear solution |
Chlorides | Note more than 0.053% | <0.053% |
Sulphate | Note more than 0.011% | <0.011% |
Heavy metal | Note more than 0.002% | <0.002% |
Loss on drying | Note more than 1.5% | 0.53% |
Benzoic acid | Not detectable | Not detected |
Thiamine | NMT 0. 1% | < 0. 1% |
Assay | ≥99.0% | 99.8% |
Arsenic | Notemore than 1 ppm | <0.04 ppm |
Cadmium | Not more than 1 ppm | <0.003 ppm |
Lead | Not more than 1 ppm | <0.04 ppm |
E coli: | Negative | Negative |
Salmonellas | Negative |
|
Conclusion | The above product conforms to JP Standard | |
Negative
