Arbutin Arbutin 497-76-7

Used as a stabilizer in color photography development; in cosmetics, it is used for skin brightening, spot removal, and hair care. A glycosylated hydroquinone used in research on melatonin biosynthesis and as an inhibitor for identifying, distinguishing, and characterizing tyrosinase. Arbutin is a glycosylated p-hydroxybenzoic acid extracted from the bearberry plant. Arbutin is a known tyrosinase inhibitor; tyrosinase, in turn, prevents the formation of melanin. Arbutin is commonly used as a skin-lightening agent in cosmetics. It works by inhibiting the activity of melanocyte tyrosinase, thereby suppressing melanin production through the inhibition of melanin synthesis.

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Model:
497-76-7
Brand:
bosschemical
Code:
497-76-7

Product Description

Arbutin Basic information
Skin Whitening Ursolic acid vs α- arbutin Photosensitivity Uses
Product Name:	Arbutin
CAS:	497-76-7
MF:	C12H16O7
MW:	272.25
EINECS:	207-850-3
Mol File:	497-76-7.mol
Arbutin Chemical Properties
Melting point	195-198 °C
alpha	-64 º (c=3)
Boiling point	375.31°C (rough estimate)
density	1.3582 (rough estimate)
refractive index	-65.5 ° (C=4, H2O)
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: 50 mg/mL hot, clear
pka	10.10±0.15(Predicted)
form	Solid
color	White
biological source	synthetic or plant
Optical Rotation	[α]/D -64.0±2.0°, c = 3 in H2O
Water Solubility	10-15 g/100 mL at 20 ºC
Sensitive	Hygroscopic
Merck	14,773
BRN	89673
Henry's Law Constant	8.2×1013 mol/(m3Pa) at 25℃, HSDB (2015)
Stability:	Stable. Hygroscopic - store under dry nitrogen.
Major Application	food and beverages
Cosmetics Ingredients Functions	ANTIOXIDANT
	SKIN CONDITIONING - MISCELLANEOUS
	BLEACHING
InChI	1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
InChIKey	BJRNKVDFDLYUGJ-RMPHRYRLSA-N
SMILES	OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
LogP	-1.35
CAS DataBase Reference	497-76-7(CAS DataBase Reference)
EPA Substance Registry System	.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)

Arbutin 497-76-7 C12H16O7 Natural food colorant Fresh-cut fruit and vegetable color protection preservative Ink colorant Rubber industry antioxidant stabilizer Textile functional finishing aid

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Controllable quality

Each batch comes with TDS/MSDS/COA; accepts third-party testing (SGS, etc.)

Chemical detection methods

Spectroscopic Analysis Methods

Ultraviolet-Vis Spectrophotometry (UV-Vis)
Infrared Spectroscopy (IR/FTIR)
Atomic Absorption Spectroscopy (AAS)
X-ray Fluorescence Spectroscopy (XRF)
Nuclear Magnetic Resonance Spectroscopy (NMR)

Chromatographic Analysis

Gas Chromatography (GC)
High Performance Liquid Chromatography (HPLC)
Ion Chromatography (IC)
Thin Layer Chromatography (TLC)

Mass Spectrometry Analysis

GC-MS / LC-MS/MS: Qualitative and Quantitative Analysis
ICP-MS: Trace Metal Elements (ppb Level)
TOF-MS: Precise Molecular Weight Determination

Electrochemical analysis methods

Polypotentiometric methods
Conductivity methods
Polarographic methods / Voltammetric methods
Coulometric analysis

Thermal Analysis Methods

Thermogravimetric Analysis (TGA)
Differential Scanning Calorimetry (DSC)
Differential Thermal Analysis (DTA)

Classical wet chemical analysis

Titration analysis
Gravity analysis