99% 2-Hydroxypropyl-β-cyclodextrin 128446-35-5 HPBCD

1. What is Hydroxypropyl-beta-cyclodextrin?

Hydroxypropyl-beta-cyclodextrin Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a hydroxypropylated derivative of β-cyclodextrin. It is one of the most commonly used modified products in the cyclodextrins. Its chemical formula is usually given as:

C63H112O42 (CAS No.: 128446-35-5, also available in a low-substitution specification 94035-02-6, molecular weight approximately 1400~1540, depending on the degree of substitution)

It is a white or off-white amorphous or crystalline powder at room temperature, odorless, slightly sweet, and extremely water-soluble (far exceeding β-cyclodextrin, reaching over 50 g/100 ml), with stable chemical properties. Hydroxypropyl-β-cyclodextrin is prepared by reacting β-cyclodextrin (containing 7 glucose units) with propylene oxide, and is one of the most water-soluble and least toxic varieties in the β-cyclodextrin series.

From a molecular structure perspective, hydroxypropyl-β-cyclodextrin molecules are cone-shaped and cylindrical, possessing a cavity structure that is hydrophobic on the inside and hydrophilic on the outside. This cavity allows it to encapsulate poorly soluble hydrophobic molecules within its space using molecular inclusion technology, thereby improving their solubility, stability, and bioavailability . In daily chemical applications, it serves as an inclusion stabilizer for active ingredients. This molecular inclusion ability constitutes the core mechanism behind its widespread application in both daily chemical and scientific research fields.

Chemically, hydroxypropyl-β-cyclodextrin is stable, non-toxic, and biocompatible. It should be stored in a dry, sealed container.

Non-food grade hydroxypropyl-β-cyclodextrin refers to products intended for use outside of food processing, primarily including reagent-grade and other specifications. Compared to food grade, non-food grade products place greater emphasis on the following indicators:

Purity and degree of substitution (DS)

The degree of substitution determines water solubility and inclusion capacity.

Moisture

Excessive moisture content affects measurement accuracy and storage stability, and must be kept at a low level.

II. What are the uses of Hydroxypropyl-beta-cyclodextrin?

1. Fragrance and flavor encapsulation and stabilization (core application)

( 1 ) Hydroxypropyl-β-cyclodextrin encapsulates flavor molecules to prevent their volatilization loss and oxidative deterioration, thereby achieving long-term stability and sustained release of flavor. It is widely used for flavoring powdered flavors, seasonings, tea drinks and baked goods.

( 2 ) By utilizing the inclusion effect, hydroxypropyl-β-cyclodextrin can effectively mask unpleasant flavors such as fishy and bitter taste in food (such as fish products, plant extracts, and polypeptide functional foods), thereby improving the taste and acceptability of food.

2. Cosmetics and Personal Care (Daily Chemical Grade)

Hydroxypropyl-β-cyclodextrin is used in cosmetics as an inclusion carrier of active ingredients to improve the stability of ingredients, sustained release of fragrances and to mask unwanted odours. It is mild and non-irritating and can be used in skin care, hair care and fragrance products. It should be used according to the technical specification of cosmetic safety.

3. Scientific research and laboratory use (Reagent grade)

Hydroxypropyl-β-cyclodextrin is a typical reagent in the area of supramolecular chemistry and molecular recognition. It is an important material in scientific research laboratories, and is used for preparation and evaluation of inclusion complexes, cell experiments and biological research.

4. Consumer grade daily use deodorising and air freshening products

Hydroxypropyl-β-cyclodextrin is widely used in daily chemical products, such as deodorants and air fresheners, and can encapsulate the odour molecules by using the inclusion-encapsulating ability of cyclodextrin, thus being applicable to home and personal deodorisation scenarios.

5. Pesticides and agrochemical adjuvants (agricultural grade)

Hydroxypropyl-β-cyclodextrin is used in formulation development of agrochemical products and can act as solubilizer and stabiliser for pesticides, which helps to formulate poorly soluble pesticides and delay the degradation of active ingredients.

6. Solubilisation and stabilisation of fat-soluble vitamins

Hydroxypropyl-β-cyclodextrin can encapsulate fat-soluble nutrients such as curcumin, vitamin D, coenzyme Q10 and ω-3 fatty acids to improve their water solubility, stability and bioavailability, and can be used in functional foods, health foods and beverages.

7. Cutting out Cholesterol (Dairy Products)

Cyclodextrin compounds can be used to encapsulate cholesterol in dairy products, removing cholesterol from egg yolks, cream and other dairy products, thereby helping with the production of low-cholesterol health foods. This is a typical example of the use of cyclodextrins in food industry.

8. Antioxidant and flavor preservation

Encapsulation can protect easily oxidised flavour compounds and nutrients from oxygen, preventing oxidative deterioration and extending the shelf life of food. It can be used to keep oily and flavoured foods fresh and preserve them.

9. Health foods and functional foods

Hydroxypropyl-β-cyclodextrin is used in inclusion complex formulations of active ingredients in health foods to improve the stability and absorption rate of the ingredients. It is applied in health foods containing vitamins and plant extracts, as well as oral liquids.

Summarize

Hydroxypropyl-beta-cyclodextrin (HP-β-CD) is a powder hydroxypropyl derivative of cyclodextrins which is white in colour. It has a cavity structure of internal hydrophobic and external hydrophilic, which greatly improves the water solubility, stability and bioavailability of poorly soluble substances by molecular inclusion technology. We are exposed indirectly in our daily lives through cosmetics, food and drink, health products, deodorisers and pesticide formulations. In the non-food field, reagent-grade hydroxypropyl-β-cyclodextrin is widely used for inclusion stabilisation of active ingredients in cosmetics, scientific research and supramolecular chemistry, daily chemical deodorising products and pesticide adjuvants, making it an important inclusion material connecting "daily use" with "health, daily chemicals and scientific research".