99.5% 1,4-Dioxane CAS 123-91-1

What is 1,4-Dioxane?

1,4-Dioxane, also known as 1,4-dioxane, is a saturated six-membered ring ether composed of four carbon atoms and two oxygen atoms. It is an important aprotic polar organic solvent in industry. Its chemical formula is usually written as:

C4H8O2 (1,4-dioxane, CAS No.: 123-91-1, molecular weight approximately 88.11)

It is a colorless, transparent liquid at room temperature with a slightly fragrant ester odor. It is miscible with water and most organic solvents. Its boiling point is 101.32℃, freezing point is 11.8℃, relative density is 1.0329, flash point is 5-18℃ (extremely flammable), and refractive index is 1.4175. The solubility of 1,4-dioxane is similar to that of dimethylformamide (DMF) and stronger than that of tetrahydrofuran (THF), and it is known as a "highly polar cyclic ether solvent between diethyl ether and DMF." This cyclic ether can undergo ring-opening reactions and coupling reactions under special conditions. Prolonged storage of 1,4-dioxane may contain peroxides; it should be tested and treated before use.

Structurally, the two oxygen atoms in the 1,4-dioxane molecule are symmetrically distributed on the six-membered ring, giving it excellent polarity, coordination ability, and thermal stability. It can dissolve cellulose esters, various resins, oils and waxes, and many polar organic compounds, making it a commonly used "universal solvent" in industrial synthesis and polymer processing.

Industrial Grade 1,4-Dioxane is 1,4-Dioxane products with purity of 99% or above, used for industrial purposes, such as resin dissolution, synthetic leather, extraction and chemical synthesis. Compared with reagent grade products, industrial grade products pay more attention to the following indicators:

1.Moisture

The moisture affects the solubility, reaction system and storage stability, especially for the anhydrous reaction system, so that it should be strictly controlled.

2.Peroxide content

Cyclic ethers are prone to oxidation and the formation of peroxides during long-term storage, which not only affects the reaction but also poses an explosion hazard. Therefore, they must be tested and controlled before use.

acidity

Acidity is a measure of the amount of free acid. The stability of the reaction system will be affected by excessive acidity, and it must be controlled within a reasonable range.

4. Boiling range (distillation range)

The boiling range is an indication of the purity and composition of a product. A narrow boiling range is indicative of high purity which is very important for solvent recovery and reuse applications.

5.Evaporation residue

Evaporation residue reflects the total amount of impurities, which is crucial for precision applications and the quality of downstream products and must be controlled within an extremely low range.

6.Chromaticity (APHA)

Color affects the appearance of downstream products; products must remain colorless and transparent.

What are the applications of industrial-grade 1,4-Dioxane?

Industrial-grade 1,4-dioxane, with its unique combination of high polarity, strong solubility, and cyclic ether structure, is widely used in chemical synthesis and polymer processing.

1.Highly polar reaction solvents (core application)

1,4-Dioxane is a highly polar aprotic solvent which is used as a reaction medium in organic production processes such as grignard reactions, organometallic reactions and condensation reactions. It helps to stabilize reactive intermediates, to improve the selectivity and yield of reactions, and is an important reaction solvent in fine chemicals.

2.Resin and polymer solvent

1,4-Dioxane has excellent solubility for cellulose esters, various resins and waxes. It is used as a reaction solvent for polyurethane synthetic leather, amino acid synthetic leather and some polymer processing, helping to control the reaction system and product properties. It is one of the important solvents in the synthetic leather industry.

3.Extractant

1,4-Dioxane is employed as a solvent in liquid-liquid extraction to aid in the separation and purification of specific organic compounds and is used in the separation processes of fine chemical engineering.

4. Stabilizer for chlorinated solvents

1,4-Dioxane has been historically used as a stabilizer for chlorinated solvents, such as 1,1,1-trichloroethane, to inhibit decomposition of chlorinated solvents and corrosion of metal containers. It is a classic application for stabilizing chlorinated hydrocarbons.

5. Synthesis of Pesticides and Fine Chemicals

1,4-Dioxane is applied to the synthesis of pesticides and fine chemicals as a reaction solvent that can improve the reaction efficiency and product purity, and is widely used in the agrochemical and fine chemical industries.Oils, waxes and coatings cosolvents

1,4-Dioxane is used as a cosolvent in oil waxes, coatings and cleaning formulations to help improve solubility and formulation compatibility. It is also used in some paint removers and industrial cleaning formulations.

6.Other applications

This includes areas such as solvent carriers for special reactions and organic synthesis research; with the progress of green solvent replacement and increasingly stringent environmental regulations, 1,4-dioxane is being replaced by more environmentally friendly solvents in some scenarios.

Summarize

1,4-Dioxane, also known as 1,4-dioxane (C4H8O2, CAS No. 123-91-1), is a colorless, transparent liquid that is miscible with water and most organic solvents. Its high polarity, strong solubility, and cyclic ether structure make it an important aprotic solvent in chemical synthesis and polymer processing. In daily life, we encounter it through synthetic leather products, pesticide production chains, drinking water environmental monitoring, and chemical products. Industrially, 1,4-dioxane is widely used as a highly polar reaction solvent, resin and synthetic leather solvent, extractant, chlorinated solvent stabilizer, pesticide and fine chemical synthesis, and oil and wax coating co-solvent.