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50-01-1
bosschem
50-01-1
Product name: Guanidine Hydrochloride
English alias: Guanidinium chloride; Aminoformamidine hydrochloride.
CAS: 50-01-1
Molecular formula: CH5N3.ClH
Appearance: White crystal
Package: 25kg/bag
Guanidine Hydrochloride is a strong chaotropic agent and one of the most powerful protein denaturants used in biochemical research and industrial applications. This highly soluble crystalline compound exhibits exceptional ability to disrupt hydrogen bonding networks, making it invaluable for protein purification, nucleic acid isolation, and various molecular biology procedures. Its strong denaturing properties and high solubility in both water and polar organic solvents make it an essential reagent in biotechnology, pharmaceutical manufacturing, and chemical synthesis.
分析项目 SPECIFICATION PROPERTIES | 技术指标 STANDARD | 实测结果 RESULTS |
外观 Appearance | 白色结晶 White crystal | 符合 Conforms |
含量 Assay,% | ≥99.0 | 100.85 |
熔点 MP,℃ | 180.0-185.0 | 183.9-184.6 |
水不溶物 Water insoluble,% | ≤0.02 | 符合 Conforms |
铵 Ammonium,% | ≤0.05 | 符合 Conforms |
灼烧残渣 Residue on ignition ,% | ≤0.02 | 0.015 |
pH 值(4%水溶液) pH Value(4% aq.) | 4.5-6.0 | 5.89 |
紫外吸光度/260nm(55%水溶液) Ultraviolet absorbance(55% aq.) | ≤0.04 | 0.012 |
紫外吸光度/280nm(55%水溶液) Ultraviolet absorbance(55% aq.) | ≤0.02 | 0.004 |
双氰胺 Dicyandiamide,% | ≤0.1 | 符合 Conforms |
三聚氰胺 Melamine,% | ≤0.01 | 符合 Conforms |
铁离子 Iron,ppm | ≤0.1 | 符合 Conforms |
干燥失重 Loss on drying,% | ≤0.3 | 0.08 |
1.Biochemical Research:
Protein denaturation and purification in chromatography
RNA isolation and purification procedures
DNA extraction and purification protocols
2.Pharmaceutical Industry:
Intermediate for antiviral drug synthesis
Active pharmaceutical ingredient in certain medications
Excipient in drug formulations
3.Molecular Biology:
Guanidine thiocyanate preparation for RNA isolation
Cell lysis and protein extraction buffers
Enzyme inactivation and stabilization
4.Industrial Applications:
Strong base in organic synthesis
Catalyst for chemical reactions
Intermediate for specialty chemicals
5.Diagnostic Reagents:
Component in diagnostic test kits
Reagent for clinical chemistry applications
6.Other Applications:
Cosmetic formulations
Photographic chemicals
Textile treatment agents
Guanidine Hydrochloride is harmful if swallowed, causes serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment including gloves, eye/face protection, and protective clothing should be worn. Handle in a well-ventilated area. Avoid formation of dust and aerosols.
keep the product dry
relative humidity < 50%
protect product against influences of weather and contamination
Guanidine Hydrochloride for technical applications is solely supplied in packaging of different sizes . It can be packaged in various items: 25 kg bags, 1000 kg bags.
Ultraviolet-Vis Spectrophotometry (UV-Vis)
Infrared Spectroscopy (IR/FTIR)
Atomic Absorption Spectroscopy (AAS)
X-ray Fluorescence Spectroscopy (XRF)
Nuclear Magnetic Resonance Spectroscopy (NMR)
Gas Chromatography (GC)
High Performance Liquid Chromatography (HPLC)
Ion Chromatography (IC)
Thin Layer Chromatography (TLC)
GC-MS / LC-MS/MS: Qualitative and Quantitative Analysis
ICP-MS: Trace Metal Elements (ppb Level)
TOF-MS: Precise Molecular Weight Determination
