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86386-73-4
bosschem
86386-73-4
| Fluconazole Basic information | |
| Product Name: | Fluconazole |
| CAS: | 86386-73-4 |
| MF: | C13H12F2N6O |
| MW: | 306.27 |
| EINECS: | 627-806-0 |
| Mol File: | 86386-73-4.mol |
| Fluconazole Chemical Properties | |
| Melting point | 138-140°C |
| Boiling point | 579.8±60.0 °C(Predicted) |
| density | 1.05 |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | solid |
| pka | pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 1g/L(temperature not stated) |
| Merck | 144,122 |
| BCS Class | 1,3 |
| InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| CAS DataBase Reference | 86386-73-4(CAS DataBase Reference) |
Tests 检验项目 | Specifications 标准规定 | Results 检验结果 | |
1 | Description 外观 | white or almost white ,crystalline powder 白色或类白色结晶性粉末 | White crystalline powder 白色结晶性粉末 |
2 | Solubility 溶解度 | Freely soluble in methanol,Soluble in alcohol,Sparingly soluble in chloroform ,slightly soluble in water and very slightly soluble in toluene. 易溶于二氯甲烷，溶于甲醇，在乙醇中略溶， 难溶于水。 | Conforms 符合规定 |
3 | Clarity and color of solutions | A 5% solution in methanol is clear and colorless | Conforms 符合规定 |
4 | Identification 鉴别 | ||
BY IR 红外鉴别 | The Infra-red absorption spectrum obtained from the sample should be concordant with spectrum obtained with that Fluconazole RS/WS. | Conforms 符合规定 | |
By UV | The UV absorption spectra of the sample solution shows absorption maxima at about 266nm and 261nm | Conforms 符合规定 | |
5 | Melthing range 溶程 | 135℃-145℃ | 139.3℃-140.5℃ |
6 | Loss on drying(% w/w) 干失 | ≤0.5 | 0.34 |
7 | Residue on ignition(% w/w) 残渣 | ≤0.1 | 0.05 |
8 | Iron(ppm) 铁 | ≤0.002 | Conforms 符合规定 |
9 | Organic impurities(%)procedure-1 有机杂质 | ||
Any impurity with RRT about 0.6 | ≤1.0% | 0.18% | |
Related compound A | ≤0.2% | 0.09% | |
Related compound B | ≤0.1% | 0.01% | |
| Fluconazole Basic information | |
| Product Name: | Fluconazole |
| CAS: | 86386-73-4 |
| MF: | C13H12F2N6O |
| MW: | 306.27 |
| EINECS: | 627-806-0 |
| Mol File: | 86386-73-4.mol |
| Fluconazole Chemical Properties | |
| Melting point | 138-140°C |
| Boiling point | 579.8±60.0 °C(Predicted) |
| density | 1.05 |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | solid |
| pka | pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 1g/L(temperature not stated) |
| Merck | 144,122 |
| BCS Class | 1,3 |
| InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| CAS DataBase Reference | 86386-73-4(CAS DataBase Reference) |
Tests 检验项目 | Specifications 标准规定 | Results 检验结果 | |
1 | Description 外观 | white or almost white ,crystalline powder 白色或类白色结晶性粉末 | White crystalline powder 白色结晶性粉末 |
2 | Solubility 溶解度 | Freely soluble in methanol,Soluble in alcohol,Sparingly soluble in chloroform ,slightly soluble in water and very slightly soluble in toluene. 易溶于二氯甲烷，溶于甲醇，在乙醇中略溶， 难溶于水。 | Conforms 符合规定 |
3 | Clarity and color of solutions | A 5% solution in methanol is clear and colorless | Conforms 符合规定 |
4 | Identification 鉴别 | ||
BY IR 红外鉴别 | The Infra-red absorption spectrum obtained from the sample should be concordant with spectrum obtained with that Fluconazole RS/WS. | Conforms 符合规定 | |
By UV | The UV absorption spectra of the sample solution shows absorption maxima at about 266nm and 261nm | Conforms 符合规定 | |
5 | Melthing range 溶程 | 135℃-145℃ | 139.3℃-140.5℃ |
6 | Loss on drying(% w/w) 干失 | ≤0.5 | 0.34 |
7 | Residue on ignition(% w/w) 残渣 | ≤0.1 | 0.05 |
8 | Iron(ppm) 铁 | ≤0.002 | Conforms 符合规定 |
9 | Organic impurities(%)procedure-1 有机杂质 | ||
Any impurity with RRT about 0.6 | ≤1.0% | 0.18% | |
Related compound A | ≤0.2% | 0.09% | |
Related compound B | ≤0.1% | 0.01% | |
