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Trifluoroacetamide Cas 354-38-1

Trifluoroacetamide (TFA) can be used to prepare N-O-bis (trimethylsilyl) trifluoroacetamide. N, O-bis, trimethylsilyltrifluoroacetamide is an important pharmaceutical intermediate, mainly used as a neutral silanizing reagent in the silanization protection of amino groups, amino acids, phenols, carboxylic acids and enols. As a mild neutral silanizing reagent, it not only has high reactivity and good selectivity, but also has the advantages of high reaction yield and simple post-treatment.
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  • 354-38-1

  • bosschemical

  • 354-38-1

           Trifluoroacetamide Basic information
Product Name: Trifluoroacetamide
CAS: 354-38-1
MF: C2H2F3NO
MW: 113.04
EINECS: 206-559-9
Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks;top;bc0001
Mol File: 354-38-1.mol
Trifluoroacetamide Chemical Properties
Melting point 65-70 °C (lit.)
Boiling point 162.5 °C (lit.)
bulk density 960kg/m3
density 1.4176 (estimate)
Fp 162-164°C
storage temp. Store below +30°C.
solubility 460 g/L (20°C)
pka 12.33±0.50(Predicted)
form Crystalline Powder or Crystals
color White to pale yellow or beige
PH 3.6 (460g/l, H2O, 23℃)
Water Solubility 460 g/L (20 ºC)
BRN 1753625
InChIKey NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP 0.725 at 23℃ and pH4.83
Dissociation constant 0 at 23℃
CAS DataBase Reference 354-38-1(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System Acetamide, 2,2,2-trifluoro- (354-38-1)

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