99% Guanidine hydrochloride CAS 50-01-1 GdnHCl

Certificate of Analysis-COA 

99% Content

 Applications 

1. Inclusion Body Solubilisation & Protein Refolding — recombinant protein recovery, E. coli inclusion bodies, refolding buffers: A strong chaotropic salt that unfolds and dissolves aggregated protein, then can be removed by dialysis or dilution so the protein refolds into its active form. Its high ionic strength also suppresses aggregation during the critical refolding step.

2. Nucleic Acid & mRNA Purification — RNA extraction, column and bead purification, mRNA manufacturing: Denatures nucleases and proteins while leaving nucleic acids intact, which is why guanidinium-based lysis buffers dominate RNA and mRNA purification. The molecular-biology grade is specified by UV absorbance so the reagent does not contribute background to the yield reading.

3. Organic Synthesis Intermediate — guanidinylation, aminoguanidine and heterocycle synthesis: The standard source of the guanidinium group, used to convert amines into guanidines and to build 2-aminoimidazolines, pyrimidines and other nitrogen heterocycles. Crystalline, water-soluble and easy to meter, unlike free guanidine.

4. Agrochemical & Dye Intermediates — crop-protection actives, guanidine-based dye chemistry: A building block for guanidine derivatives used in crop protection and for dye intermediates where the guanidinium group provides hydrogen bonding and salt-forming sites.

5. Guanidine Salt & Derivative Manufacturing — free guanidine, guanidine nitrate, carbonate and thiocyanate production: A convenient, stable, high-assay feedstock for producing other guanidine salts by ion exchange or metathesis, avoiding the handling problems of free guanidine base.

 Quality Assurance 

Every batch of chemicals leaves our factory with complete laboratory documentation — not a promise, but verifiable test data. From incoming raw material inspection to finished-goods release, each batch is tested against published specifications, and a Certificate of Analysis (COA) accompanies every single shipment. What you order is exactly what we test — and what we ship.

Tested by our in-house ISO 9001:2015 laboratory. Verified independently by third-party labs on request (SGS / BV / Intertek). Traceable from raw material to your warehouse.

 Packaging 

White woven bags

Kraft paper bags

Big bags

Export-grade packaging, custom labels

Solids (woven bags/cardboard drums/ton bags)

Liquids (plastic drums/IBC/ISO tanks)