|Methotrexate Basic information|
|Treatment of cancer and rheumatoid arthritis History of discovery Immunosuppressants Pharmacological effects Pharmacokinetics Clinical application Dosage Adverse reactions and precautions Drug Interactions Chemical Properties Production method|
|Synonyms:||METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe|
|Product Categories:||Inhibitor;Anti-cancer&immunity;Aromatics;Bases & Related Reagents;Chiral Reagents;API;Aromatic Esters;Antibiotics for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;API’s;Antitumour;Heterocycles;Nucleotides;Others (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors|
|Methotrexate Chemical Properties|
|alpha||+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)|
|Boiling point||561.26°C (rough estimate)|
|density||1.4080 (rough estimate)|
|refractive index||1.6910 (estimate)|
|storage temp.||Keep in dark place,Inert atmosphere,Store in freezer, under -20°C|
|pka||pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)|
|Water Solubility||Insoluble. <0.1 g/100 mL at 19 ºC|
|Sensitive||Light Sensitive & Hygroscopic|
|Stability:||Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.|
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